Adult Hodgkin lymphoma is a disease in which malignant
(cancer) cells form in the lymph system.
There are two main types of Hodgkin lymphoma: classical and nodular lymphocyte-predominant.
Age, gender, and Epstein-Barr infection can affect
the risk of adult Hodgkin lymphoma.
Signs of adult Hodgkin lymphoma include swollen lymph
nodes, fever, night sweats, and weight loss.
Tests that examine the lymph nodes are used to detect (find)
and diagnose adult Hodgkin lymphoma.
Certain factors affect prognosis (chance
of recovery) and treatment options.
Adult Hodgkin lymphoma is a disease in which malignant
(cancer) cells form in the lymph system.
Adult Hodgkin lymphoma
is a type of cancer
that develops in the lymph system, part of the body's immune system. The immune system protects the body from foreign substances, infection, and diseases. The lymph system is made up of the following:
Lymph
: Colorless,
watery fluid
that carries white blood cells
called lymphocytes
through the lymph system. Lymphocytes protect the
body against infections and the
growth of tumors.
Lymph vessels
: A network of thin tubes that collect lymph
from different parts of the body and return it to the bloodstream.
Lymph nodes
:
Small, bean-shaped structures that filter lymph and store white blood cells that help fight
infection and disease. Lymph nodes are located along the network of lymph vessels
found throughout the body. Clusters of lymph nodes are found in the neck, underarm, abdomen, pelvis, and groin.
Spleen
: An organ
that makes lymphocytes, filters the blood, stores blood cells, and destroys
old blood cells. It is located on the left side of the abdomen near the stomach.
Thymus
: An organ
in which lymphocytes grow and multiply. The thymus is in the chest behind the breastbone.
Tonsils
: Two small
masses of lymph tissue
at the
back of the throat. The tonsils make lymphocytes.
Anatomy of the lymph system, showing the lymph vessels and lymph organs including lymph nodes, tonsils, thymus, spleen, and bone marrow. Lymph (clear fluid) and lymphocytes travel through the lymph vessels and into the lymph nodes where the lymphocytes destroy harmful substances. The lymph enters the blood through a large vein near the heart.
Lymph tissue is also found in other parts of the body such as the stomach, thyroid gland, brain, and skin. Cancer can spread to the liver
and lungs.
Hodgkin lymphoma can occur in both adults and children. Treatment for adults is different than treatment for children. Hodgkin lymphoma may also occur in patients who have acquired immunodeficiency syndrome
(AIDS); these
patients require special treatment.
See
the following PDQ summaries for more information:
Hodgkin lymphoma in pregnant
women is the same as the disease in nonpregnant women of childbearing age. However, treatment is different for pregnant women. This summary includes information about treating Hodgkin lymphoma during pregnancy.
There are two main types of Hodgkin lymphoma: classical and nodular lymphocyte-predominant.
Most Hodgkin lymphomas are the classical
type. The classical type is broken down into the following four subtypes:
Nodular sclerosing Hodgkin lymphoma.
Mixed cellularity Hodgkin lymphoma.
Lymphocyte depletion Hodgkin lymphoma.
Lymphocyte-rich classical Hodgkin lymphoma.
Age, gender, and Epstein-Barr infection can affect
the risk of adult Hodgkin lymphoma.
Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your doctor if you think you may be at risk. Risk factors for adult
Hodgkin lymphoma include the following:
Pregnancy is not a risk factor for Hodgkin lymphoma.
Signs of adult Hodgkin lymphoma include swollen lymph
nodes, fever, night sweats, and weight loss.
These and other signs
and symptoms
may be caused by adult Hodgkin lymphoma or by other conditions.
Check with your doctor if any of the following do not go away:
Painless, swollen lymph nodes in the neck, underarm, or
groin.
Tests that examine the lymph nodes are used to detect (find)
and diagnose adult Hodgkin lymphoma.
The following tests and procedures may be used:
Physical exam
and history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient's past illnesses and treatments will also be taken.
Complete blood count
(CBC): A procedure in which a sample of blood is drawn and
checked for the following:
The number of red blood cells, white blood cells, and
platelets.
The portion of the sample made up of red blood
cells.
Complete blood count (CBC). Blood is collected by inserting a needle into a vein and allowing the blood to flow into a tube. The blood sample is sent to the laboratory and the red blood cells, white blood cells, and platelets are counted. The CBC is used to test for, diagnose, and monitor many different conditions.
Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by
organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign
of disease.
Sedimentation rate: A procedure in which a sample of blood is drawn and checked for the rate at which the red blood cells settle to the bottom of the test tube. The sedimentation rate is a measure of how much inflammation
is in the body. A higher than normal sedimentation rate may be a sign of lymphoma or another condition. Also called erythrocyte sedimentation rate, sed rate, or ESR.
Lymph node biopsy:
The removal of all or part of a lymph node. One of the following types of
biopsies may be done:
Core biopsy: The removal of part of a lymph node using a wide needle.
A pathologist
views the tissue under a microscope
to look for cancer cells, especially Reed-Sternberg cells. Reed-Sternberg cells are common in classical Hodgkin lymphoma.Reed-Sternberg cell. Reed-Sternberg cells are large, abnormal lymphocytes that may contain more than one nucleus. These cells are found in Hodgkin lymphoma.
The following test may be done on tissue that was removed:
Immunophenotyping: A laboratory test
used to identify cells, based on the types of antigens
or markers
on the surface of the cell. This test is used to diagnose
the specific type of lymphoma by comparing the cancer cells to normal cells of the immune system.
Certain factors affect prognosis (chance
of recovery) and treatment options.
The prognosis
(chance of recovery) and treatment options depend on the following:
