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Treatment Options for Childhood CNS Germ Cell Tumors

Newly Diagnosed CNS Germinomas

Treatment of newly diagnosed central nervous system (CNS) germinomas may include the following:

Newly Diagnosed CNS Teratomas

Treatment of newly diagnosed mature and immature central nervous system (CNS) teratomas may include the following:

Newly Diagnosed CNS Nongerminomas

It is not clear what treatment is best for newly diagnosed central nervous system (CNS) nongerminomas is. Treatment of choriocarcinoma, embryonal carcinoma, yolk sac tumor, or mixed germ cell tumor may include the following:

  • Chemotherapy followed by radiation therapy. If a mass remains after chemotherapy, surgery may be needed to check if the mass is a mature teratoma, fibrosis, or a growing tumor.
    • If the mass is a mature teratoma or fibrosis, radiation therapy is given.
    • If the mass is a growing tumor, other treatments may be given.
  • Surgery to remove as much of the mass as possible and check for tumor cells, if tumor marker levels are normal and the mass continues to grow (called growing teratoma syndrome).
  • A clinical trial of chemotherapy followed by radiation therapy given in lower doses depending on how the tumor responds to treatment.

Recurrent Childhood CNS Germ Cell Tumors

Treatment of recurrent childhood central nervous system (CNS) germ cell tumors may include the following:


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